Cisplatin lysosomes

Author: rozr

August undefined, 2024

WebSep 25, 2024 · We investigated whether triggering lysosomal membrane permeabilization (LMP) or suppressing autophagy can restore cisplatin susceptibility in lung cancer with … WebCisplatin, a class of platinum-containing anticancer drugs for the treatment of solid tumors, is a substrate of OCT2 and MATE1/MATE2-K. OCT2 is expressed in the basolateral …

interplay between exosomes and autophagy – partners in crime

WebCisplatin is a chemotherapy drug which is used to treat cancers including: sarcoma, small cell lung cancer, germ cell tumors, lymphoma, and ovarian cancer. While it is often … WebOct 14, 2005 · Lysosomes are an essential part of the vesicular compartment and connect the outside medium with many classes of cellular targets in the cytosol, nucleus, … i release all anger because anger harms me

Reduced endocytosis and altered lysosome function in cisplatin …

WebNCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. WebJun 5, 2024 · Disrupting lysosomes with bafilomycin A1 increased the sensitivity of resistant cells to CDDP (Fig. 2K ). Fig. 2: Therapy-activated TFEB acts as a critical regulator to control lysosomal... WebLysosome Fe 2+ release is responsible for etoposide- and cisplatin-induced stemness of small cell lung cancer cells Iron metabolism has been shown to hand over cancer stem cell, which is regarded as the root of tumor progression, recurrence and chemoresistance. i release all that does not serve me

MiTF is Associated with Chemoresistance to Cisplatin in A549 …

Insights into RNA binding by the anticancer drug cisplatin …

WebOct 13, 2024 · Cisplatin is an inorganic platinum derivative that is widely used for chemotherapy of various solid tumours. In cancer cells, cisplatin induces DNA crosslinks and DNA adducts, triggering the... WebSep 21, 2015 · Platinum-based cisplatin is a first-line therapeutic agent used in the treatment of multiple cancers, including ovarian cancer. Cisplatin acts by inducing DNA damage, triggering cell cycle arrest, and initiating apoptosis ( 4 ). However, many ovarian cancer patients develop acquired cisplatin resistance, resulting in failure of … i release from all legal liabilityWebNov 7, 2024 · Cisplatin (cis-diamminedichloroplatinum (II)) is a square-planar geometry platinum coordination compound synthesized for the first time in 1844. Its cytotoxic properties were discovered in the 1970s and since its approval by FDA for cancer therapy in 1978 it has become one of the most commonly used drugs in the treatment of human … i release myself from claim liability

"WebAutophagy is defined as the process of intracellular degradation of cytoplasmic materials in the lysosome; however, the correlation between autophagy and drug resistance remains controversial. ... The cisplatin (DDP)-resistant human lung adenocarcinoma A549 cell line (A549/DDP) and its parental A549 cell line were purchased from Rui Cong ... " - Cisplatin lysosomes

Cisplatin lysosomes

Reduced endocytosis and altered lysosome function in cisplatin ...

WebWestern blotting showed that cisplatin decreased protein expression of E6 and increased protein expression of p53, p21 and Bax. It had no effect on protein expression of Bcl-2. It is concluded that cisplatin can induce apoptosis in HeLa cells by suppressing HPV E6 and thereby restoring the function of p53. Publication types WebDec 8, 2024 · Cisplatin, activated by intracellular hydrolysis of chlorides, binds to DNA to form monoadducts as well as intra- and interstrand DNA cross-links [ 3 ]. As a result, it …

Did you know?

WebSep 25, 2024 · We investigated whether triggering lysosomal membrane permeabilization (LMP) or suppressing autophagy can restore cisplatin … WebLysosomes are specialized organelles for protein recycling and as such are involved in the terminal steps of autophagy. However, it has become evident that lysosomes also play an important role in the progression of apoptosis.

WebLysosome-associated membrane protein (LAMP)-1, one of the major protein components of the lysosomal membrane, is upregulated in the human glioblastoma cell lines, U-373 MG and LN-Z308, which undergo cisplatin-induced apoptosis. These human brain tumor cell lines demonstrated apoptosis in response to … WebCytoplasmic material is transported to lysosomes for degradation and recovery through autophagy. ... Y. et al. Cisplatin-induced autophagy protects breast cancer cells from apoptosis by regulating ...

WebApr 22, 2003 · We isolated human KB adenocarcinoma cisplatin-resistant (CP-r) cell lines with multidrug-resistance phenotypes because of reduced accumulation of cisplatin and other cytotoxic compounds such as methotrexate and heavy metals.

WebAug 3, 2024 · The eukaryotic endomembrane system (EMS) is a set of interrelated membrane-bound organelles that include the endoplasmic reticulum (ER), Golgi, lysosome and the plasma membrane, as well as the vesicles trafficking between them. It is responsible for numerous cellular processes, such as endocytosis and exocytosis.

WebMar 1, 2024 · Cisplatin (CDDP) is a widely used agent in the treatment of neuroblastoma. Unfortunately, the development of acquired chemoresistance limits its clinical use. To gain a detailed understanding of the mechanisms underlying the development of such chemoresistance, we comparatively analyzed established … i relish the factWebConfocal microscopy studies for 2a-Cl suggest that complexes localize preferentially in the lysosomes and to a lesser extent on the cytoplasm, but ultimately causing damage to the mitochondria. Finally, the potential photodynamic behaviour of scarcely toxic complexes 2b-Cl, 2b-PF6, 2c-Cl and 3a-PF6 was also studied i relly try baWebApr 15, 2003 · Cisplatin (CP) is a component of standard treatment regimens for testicular, ovarian, bladder, cervical, head and neck and small-cell and nonsmall-cell lung cancers (Ozols and Williams, 1989 ... i release and let goWebApr 26, 2016 · Doxorubicin blocks autophagic flux in cardiomyocytes by impairing lysosome acidification and lysosomal function. Reducing autophagy initiation protects against doxorubicin cardiotoxicity. Doxorubicin blocks autophagic flux in cardiomyocytes by impairing lysosome acidification and lysosomal function. i release what no longer serves meWebOct 1, 2024 · Cisplatin, sequestered in the lysosome is freed by the LMP action of CPTNPs, allowing for increased availability of cisplatin and increased cell death. (For … i relieved to hearWebLysosomes have been proposed to sequester drugs, including cisplatin, and may therefore contribute to drug resistance. However, the mechanism(s) that facilitate this remains unclear. Our work demonstrates that the CACC TMEM16A drives lysosomal … We would like to show you a description here but the site won’t allow us. i relief eye hmask amazonot coldWebOct 1, 2024 · The Lysosomal pH shift induces nanofibril formation and lysosomal membrane permeation, thereby releasing the lysosomal contents into the cytoplasm and inducing LMP mediated cell death and cisplatin sensitization. Figure … i relly want to stay at your house下载